August 7, 2009
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Gut Check I: A novel function for the gut hormone cholecystokinin (CCK) was discovered by Tony Lam’s research team at the Toronto General Research Institute and made the cover story in Cell Metabolism this week. Activation of the CCK hormone sends a signal to the brain and then to the liver to trigger lower sugar production. However, resistance to CCK occurs following high-fat feeding and corresponds to elevated blood sugar levels. This work follows a series of ground-breaking discoveries by Tony Lam’s group over the last few years identifying a novel gut-brain-liver neuronal circuitry regulating glucose production, which presents an alternate approach to combating obesity and diabetes.
Gut Check II: There are trillions of friendly bacteria in our lower intestines that play an important role in maintaining a healthy gastrointestinal system. Our innate immune system, which includes Toll-like receptor signaling, detects and keeps these microbes compartmentalized in the gut. But what would happen if this innate immune system is compromised? A study published in this week’s issue of Science by Dr. AJ Macpherson at McMaster University used a mouse model deficient in innate immune responses (i.e. lacking Toll-like receptors) to demonstrate that intestinal bacteria escapees into the body trigger a cooperative response from the adaptive immune system (e.g. antibodies) to compensate and maintain the host-bacteria mutualism.
My Space – for Stem Cells: Stem cells need their personal space too. Some important signaling pathways are regulated by the size of the colony and niche and can influence stem cell fate. Peter Zandstra’s Stem Cell Bioengineering Lab at the University of Toronto completed an intricate study that defined the spatial parameters of the stem cell microenvironment and hinted that these factors should be considered when planning experiments and interpreting results.
Muscle wasting in Cystic Fibrosis: Patients with Cystic Fibrosis usually experience muscle atrophy and it was previously thought to be a secondary effect of the disease. New evidence presented in this PLoS – Genetics article by Dr. Basil Petrof’s group at McGill University Health Centre shows that muscle loss may be predisposed, a direct symptom of mutations in the CFTR gene in muscle cells. In addition to abnormal calcium levels, CFTR-deficient muscle cells exhibit an elevated inflammatory response and upregulation of genes associated with protein degradation or muscle atrophy. These results have implications for current treatments to more aggressively control inflammation and target calcium homeostasis.
July 9, 2009
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Over to you, White House press release:
“President Obama said, ‘The National Institutes of Health stands as a model when it comes to science and research. My administration is committed to promoting scientific integrity and pioneering scientific research and I am confident that Dr. Francis Collins will lead the NIH to achieve these goals. Dr. Collins is one of the top scientists in the world, and his groundbreaking work has changed the very ways we consider our health and examine disease. I look forward to working with him in the months and years ahead.'”
Bonus: See this very well-timed (if not very optimistic) piece in Nature News today on the 20th anniversary of the discovery of the CF gene (by Collins and Lap-Chee Tsui, the latter then at Sick Kids in Toronto).
Bonus #2 — Three Degrees of Francis Collins: I did my Ph.D. in Doug Bishop’s lab. Doug did his post-doc in Nancy Kleckner’s lab. Nancy and Francis Collins were elected to the National Academy of Sciences together in 1993. Ta da! Your turn…
February 18, 2009
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Good thing I waited until evening, because this week’s post is mammoth. Funny, right? So funny, this post may go viral…
And on the topic of vaccines, the U.S. vaccine court issued three different rulings on a group of vaccine-autism claims, and didn’t mince words. The three Special Masters found the claims “speculative and unpersuasive,” “overwhelmingly contrary” to the evidence and relying on “scientifically flawed or unreliable articles”, respectively.
Last but not least, a few viruses turned up in new and interesting places: