The Cross-Border Biotech Blog

Biotechnology, Health and Business in Canada, the United States and Worldwide

Friday Science Review: Timing Is Everything Edition

ErlenmeyersSome interesting clinical studies in the New England Journal and in JAMA this week from Canadian researchers show the importance of timing interventions and medications properly. Read on

Timing for Angiography:  A NEJM paper from a group out of McMaster University led by Dr. Shamir Mehta performed a prospective randomized trial to assess the timing of coronary angiography following presentation with acute coronary syndromes.  They compared intervention at or under 24 hours to intervention at or after 36 hours.  Although the primary outcomes did not show a significant difference, there was a significant difference in the composite secondary outcome of death, myocardial infarction, or refractory ischemia that “showed early intervention to be superior to delayed intervention in high-risk patients.”

Timing for Insomnia Drugs: A paper in JAMA from Charles Morin’s group at Université Laval showed that for

“patients with persistent insomnia, the addition of medication to [Cognitive Behaviour Therapy (‘CBT’)] produced added benefits during acute therapy, but long-term outcome was optimized when medication is discontinued during maintenance CBT.”

Timing for Cataract Surgery:  Another Canadian JAMA paper in the May 20th issue comes from Chaim Bell et al. out of St. Mike’s in Toronto.  It takes a retrospective look at cataract surgeries and shows a significant association between administration of the alpha-adrenergic receptor blocker tamsulosin — given for benign prostatic hyperplasia (“BPH”) to many men in the applicable age group — and adverse ophthalmic events following cataract surgery.  Interestingly, there were no significant associations with exposure to other alpha-blocker medications used to treat BPH.


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