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Biotechnology, Health and Business in Canada, the United States and Worldwide

Tag Archives: NEJM

Friday Science Review: Timing Is Everything Edition

ErlenmeyersSome interesting clinical studies in the New England Journal and in JAMA this week from Canadian researchers show the importance of timing interventions and medications properly. Read on after the jump…

Friday Science Review: Sunday Edition

ErlenmeyersHello, loyal readers.  Welcome to the Sunday Edition of the Friday Science Review.  Sorry for the delay … turns out my day job is sometimes a day and night and next day and next night job.  Anyway, this one’s worth the wait.  Lots of cool science on a cool Spring weekend here in Canada after the jump…

Warfarin and Personalized Medicine

dna_sequenceThe optimal dose of Warfarin for an individual can vary across a 10-fold range, and depends in part on genetic variation in two genes, CYP2C9 and VKORC1.  In 2007, the FDA required a labelling change to warn of patients with increased risk of bleeding due to these variations.  However, population-wide assessments of outcomes based on genetic testing were not definitive.

A paper in the current issue of the New England Journal of Medicine uses retrospective data to build a new dosing algorithm and predicts significant benefit from the use of the algorithm for the 46% of patients who require lower- or higher-than-normal doses.  The algorithm and data used to derive it will be made available via PharmGKB, a database managed by researchers at Stanford, and the research has prompted a full-scale prospective study of the personalized approach.

Frank M. Torti, M.D., acting commissioner of Food and Drugs said that the prospective study

is precisely what is needed to advance the promise of personalized medicine, ensuring that patients receive the safest and most effective drug dose.

Read our other posts on personalized medicine.
 

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Friday Science Review: February 6, 2009

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