The Cross-Border Biotech Blog

TK/GCV Suicide Gene Therapy: Connecting the Dots Laval University ♦ Published in Cancer Gene Therapy (npg), July 22, 2011 Glioblastoma is an aggressive form of brain cancer requiring intensive therapy. Even with surgery, chemotherapy, and radiation, the mean survival time is approximately one year. A new therapeutic paradigm is currently being investigated in clinical trials, [...]

Genetic Basis for Gray Platelet Syndrome Hospital for Sick Children ♦ University of Toronto ♦ University of Colorado ♦ University of Utah ♦ Others.. Published in Nature Genetics, July 17, 2011 Researchers have found a mutation in the gene NBEAL2 which seems to be at the root of Gray Platelet Syndrome (GPS), a disorder characterized [...]

New Target for AML British Columbia Cancer Agency ♦ University of British Columbia ♦ Hannover Medical School ♦ Stanford University School of Medicine Published in Cancer Cell, July 12, 2011 The MN1 locus is implicated in the development of acute myeloid leukemia (AML), where its up-regulation is a poor prognostic marker. Not all progenitors are [...]

Reductive DNA Damage, A New Evil University of Waterloo ♦ University Health Network ♦ University of Toronto ♦ Published in PNAS, July 5, 2011 The mechanism behind oxidative DNA damage is well known. It has long been thought that oxidative damage causes the majority of DNA damage in a cell, leading to malignant transformation and [...]