http://crossborderbiotech.ca/2009/08/14/friday-science-review-august-14-2009/ Biotechnology, Health and Business in Canada, the United States and Worldwide Sat, 10 Dec 2011 04:09:15 +0000 hourly 1 http://wordpress.com/ http://crossborderbiotech.ca/2009/08/14/friday-science-review-august-14-2009/comment-page-1/#comment-859 Fri, 21 Aug 2009 14:06:38 +0000 http://crossborderbiotech.ca/?p=2907#comment-859 [...] Understanding Stat3 in Breast Cancer: Elevated Stat3 levels in breast cancer patients often correlates with poor clinical outcome.  To understand how Stat3 may influence cancer progression, a Stat3 knockout mouse was combined with a mouse expressing the mutant form of the breast cancer gene, ErbB2, and predisposed to develop breast tumours.  What the researchers at McGill University found was that without Stat3, breast cancer still developed but the malignancy of the mammary tumours decreased significantly with fewer animals having metastatic lesions in the lung.  Genetic profiling of the tumours showed that without Stat3, angiogenic and inflammatory responses, which often play an important role in the metastatic process, were blunted.  Remember, last week I noted an article on Par6 and TGFb in breast cancer metastasis. [...]

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